Tiredness, low energy, or muscle weakness (also called fatigue). Intermediate forms of thalassemia can cause mild to moderate anemia and may be associated with other health problems such as slowed growth, delayed puberty, bone … The signs and symptoms vary depending on the severity of the thalassemia. What if one parent has alpha thalassemia trait and the other parent is a silent carrier? Learn more about thalassemia, also known as Mediterranean Anemia, Cooley's Anemia or Homozygous Beta Thalassemia, and possible signs, symptoms, and treatment options for both thalassemia trait and tha There are two subtypes of the disorder (alpha and beta) depending on what portion of the hemoglobin is abnormally synthesized. What are the Symptoms of Thalassemia? Some such cases result from an autosomal dominant form of thalassemia and others from inheriting a mutation that is not detected by the probes utilized in the DNA testing. Thalassemia is an inherited blood disorder. A person may have alpha or beta thalassemia, and symptoms … General Symptoms of Thalassemia. The signs and symptoms you experience depend on the type and severity of your condition. Thalassemia minor. It leads to a decrease in overall hemoglobin levels, with the characteristic signs and symptoms of anemia.. Signs and symptoms of alpha thalassemia are those of other types of anemia and include. Thalassemia symptoms depend on the type of thalassemia you have and the severity of the anemia. People who have alpha thalassemia trait have red blood cells that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single red blood cell), and have a mild chronic anemia. Beta Thalassemia trait: Introduction. Beta Thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. Some people have little or even no symptoms. Your symptoms will depend on the category of thalassemia you have. Symptoms of thalassemia may include one or more of the following: Paleness. Beta-thalassemia. Alpha thalassemia is an inherited blood disorder that affects the way hemoglobin (the molecule that carries iron and oxygen in the blood) is produced. Symptoms of thalassemia. For example, people affected by milder forms of thalassemia can develop mild anemia or may have no signs or symptoms of the condition at all. Mild forms of thalassemia trait don't need treatment. If it does, it causes minor anemia. fatigue [ citation needed ] Hemoglobin S /thalassemia: common in African and Mediterranean populations, is clinically similar to sickle-cell anemia , with the additional feature of splenomegaly . Hemoglobin E/thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or thalassemia intermedia. People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not suffer from any health problems except a mild anemia. This is why it is also sometimes referred to as Mediterranean anemia. It inhibits the production of hemoglobin and red blood cells. A person may have either alpha thalassemia trait or beta thalassemia trait, depending upon which form of … Some babies show signs and symptoms of thalassemia at birth, while others may develop them during the first two years of life. For moderate to severe thalassemia, treatments might include: Frequent blood transfusions. Other people have mild to severe symptoms. If one parent has the cis form of alpha thalassemia trait (αα/--), and the other parent is a silent carrier (αα/α-), there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin H disease. 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