The pharmacokinetics of carboplatin and etoposide were studied in four testicular teratoma patients receiving four courses each of combination chemotherapy consisting of etoposide (120 mg/m2 daily x 3); bleomycin (30 mg weekly) and carboplatin. Clipboard, Search History, and several other advanced features are temporarily unavailable. Purpose: The present study was undertaken to determine the effects of dexamethasone (DEX) pretreatment on antitumor activity and pharmacokinetics of the cancer chemotherapeutic agents carboplatin and gemcitabine. Relationships between pharmacokinetics (area under the curve) and pharmacodynamics (extent of myelosuppression or extent of existing kidney failure) have allowed the development of equations for rational dosage reduction. The urinary excretion of platinum (0 to 24 hours) accounted for 58 to 72% of doses in 12 to 24 hours. Pharmacokinetic studies were thus conducted to confirm that the target AUC . Patients and methods: The pharmacokinetics of carboplatin were analyzed in 30 patients with advanced lung cancer receiving a total of 48 cycles of carboplatin plus paclitaxel/ docetaxel combination chemotherapy. A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics in 18 patients with pretreatment glomerular filtration rates (GFR) in the range of 33 to 136 mL/min. L J van Warmerdam Department of Medical Oncology, Antoni van Leeuwenhoek Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Szikriszt B, Pti , Nmeth E, Kanu N, Swanton C, Szts D. Mutagenesis. Neoplasia. Both patients gave written consent before starting the pharmacokinetic studies. Plasma free platinum (less than 50,000 mol. Comparative adverse effect profiles of platinum drugs. -, Semin Oncol. Purpose To determine the pharmacokinetics of adaptively dosed carboplatin when administered in combination with the bradykinin agonist, lobradimil (RMP-7, Cereport), to pediatric patients with brain tumors. 2004;21(1):9-20. doi: 10.1385/MO:21:1:09. Absorption Bioavailability FOIA The objectives of the analysis were to evaluate the effect of baseline covariates and co-administration of topotecan plus carboplatin (T + C) on pharmacokinetics of . Found inside Page 596Carboplatin pharmacokinetics in children : the development of a pediatric dosing formula . J Clin Oncol . 1993 ; 11 : 2314-2323 . 137. In contrast to results from animal studies, the modulation of carboplatin-induced myelosuppression by diethyldithiocarbamate (DDTC) was not clinically successful. Pharmacokinetics and pharmacodynamics of carboplatin administered in a high-dose combination regimen with thiotepa, cyclophosphamide and peripheral stem cell support. Since simultaneous combined treatment with intrapleural DDP and CBDCA has not been reported in humans, we investigated its use in patients with malignant effusions, focusing on pharmacokinetics. The carboplatin dose was calculated so as to achieve a constant area under the plasma concentration . Total plasma and urine platinum and plasma ultrafilterable platinum concentrations were determined by atomic absorption spectrometry. 8600 Rockville Pike The aim of this pharmacokinetic/pharmacodynamic study was to define the relationships of the carboplatin exposure with the toxicity in patients treated with high dose carboplatin (400 mg m-2. The chemical name for Carboplatin, USP is platinum, diammine [1,1-cyclobutanedicarboxylato (2-)-O,O']-, (SP-4-2), and Carboplatin, USP has the following structural formula: Carboplatin, USP is a white to off white crystalline solid. The pharmacokinetics of carboplatin, ultrafilterable platinum, and total platinum after intraperitoneal (i.p.) Two patients experienced dose-limiting toxicity (DLT) at the first dose level (carboplatin AUC 5, bortezomib .5mg/m2), prompting carboplatin reduction to AUC 4 for subsequent dose levels. Objectives Carboplatin is frequently used in various doses for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of epithelial ovarian cancer (EOC) although its pharmacokinetics, including focus on the perfusion time, has not been evaluated when used in modern era cytoreductive surgery (CRS). Patients re-ceived the Taxol before the first or second carboplatin dose by random assignment. The pharmacokinetics of carboplatin were investigated in cancer patients after single, IV infusion doses of 75, 150, 247.5, 300, 375, and 450 mg/m2. Background. Carboplatin was a Clinical pharmacokinetics of carboplatin 1986 Jan 15;57(2):222-5 Carboplatin, therefore, exhibits linear pharmacokinetics over the Raynaud FI, Boxall FE, Goddard PM, Valenti M, Jones M, Murrer BA, Abrams M, Kelland LR. Found inside Page 529Phase I clinical trial and pharmacokinetics of carboplatin [NSC 241240] by single monthly 30-minute infusion. Cancer. 1986 Jan 15;57[2]:222-5 Trump DL, Carboplatin, therefore, exhibits linear pharmacokinetics over the dosing range studied (300 mg/m 2 to 500 mg/m 2). Crp (P < 0.05) and 1/[Crp] (P < 0.01) were significantly associated with Cmax. 1989 Apr;16(2 Suppl 5):14-8 Carboplatin is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma; and as preparation for a stem cell or bone marrow transplant. NSC-241240; Pharmacology Indication. These 3 species have been measured as a function of time in biological fluids and tissues to determine their pharmacokinetics. In addition, experimental data to characterize pharmacokinetics of gemcitabine and carboplatin were not available. wt) pharmacokinetics have been studied in eight patients treated with high-dose (800-1600 mg/m2) carboplatin as a 1 h infusion with moderate hydration. In contrast, the pharmacokinetics of carboplatin were altered, with doubled half-lives compared to patients with normal renal function. The end point of the study . Maximum plasma concentrations (Cmax) and area under the plasma concentration time curve (AUC) increased proportionally with dose. Evaluating patient-specific neoadjuvant regimens for breast cancer via a mathematical model constrained by quantitative magnetic resonance imaging data. Bethesda, MD 20894, Copyright Key words: carboplatin, pharmacokinetics, population, paediatrics EwJ Cancer, Vol. Actual Study Completion Date : October 2015. A Randomized, double-blind, placebo-controlled, multi-center Phase 3 study evaluating efficacy, safety and pharmacokinetics of Trilaciclib In Extensive-Stage Small Cell Lung Cancer Patients Receiving Carboplatin combined with Etoposide or Topotecan The study consists of 2 parts: Part 1: safety run-in and pharmacokinetics evaluation of 12 ES-SCLC patients (6 each for first line and second/third . Found inside Page 192 M.E. Gore and E. Wiltshaw, Carboplatin dosage: prospective evaluation of a I.J. Lewis, C.R. Pinkerton and M.C. Stevens, Carboplatin pharmacokinetics In the univariate analysis, age was significantly related to Cmax (P = 0.0303), AUC (P = 0.0050), Ct (P = 0.0020), Cr (P = 0.0092). Cisplatin and carboplatin pharmacokinetics in a pediatric patient with hepatoblastoma receiving peritoneal dialysis A. Laura Nijstad, Natasha K. A. van Eijkelenburg, Kathelijne C. J . The lower reactivity with proteins may be related to the observed reduction in nephrotoxicity. Newell are at the Cancer Research Unit . Carboplatin is a less potent, less emetogenic and much less nephrotoxic analog of cisplatin. This site needs JavaScript to work properly. To minimize patient loss from the trial, the carboplatin dose was split, and half administered in successive weeks. A population pharmacokinetic study using the NONMEM program was undertaken to determine the effects of a variety of covariates on the clearance of ultrafilterable carboplatin. These studies were considered an integral part of the treatment protocol for the patents and were performed in accordance with institutional guidelines. -. This value most probably represents the breakdown of proteins to which both compounds are irreversibly bound. MeSH Would you like email updates of new search results. 2021 Jul 6;10(14):3016. doi: 10.3390/jcm10143016. Experimental Design: Oxaliplatin (7 or 5 mg/kg), cisplatin (2 mg/kg), or carboplatin (10 mg/kg) was given i.v. FOIA Found inside(2006) Activation of carboplatin by carbonate. 18. van der Vijgh, W.J.F. (1991) Clinical pharmacokinetics of carboplatin. Clinical Pharmacokinetics, 21 The pharmacokinetics of carboplatin in cerebrospinal fluid (CSF) and plasma was studied in five children with brain tumors (four medulloblastomas and one ependimoblastoma) who underwent preirradiation treatment with carboplatin. Carboplatin has a similar spectrum of activity to cisplatin. Accessibility -, Cancer Chemother Pharmacol. 2 Found insidePhase I clinical and pharmacokinetic study of high-dose mitoxantrone combined with carboplatin, cyclophosphamide, and autologous bone marrow rescue: high Careers. Modified Pediatric Calvert Equations Marina et al. Carboplatin (5mg/rat) in 0.5ml poloxamer 407 (1.0 ml total volume) was administered subcutaneously in a right subcutaneous perineal incision in all 12 treatment rats. Please enable it to take advantage of the complete set of features! Conclusions: Jane M Dobson, . Experimental Design: Antitumor activities of carboplatin and gemcitabine with or without DEX pretreatment were determined in six murine-human cancer xenograft models, including . Journal Article (Clinical Trial;Journal Article) PURPOSE: The pharmacokinetic parameters and maximal tolerated systemic exposure were determined for carboplatin in young children given in combination with cyclophosphamide and etoposide. Carboplatin [diammine(1,1-cyclobutanedicarboxylato)platinum(II)] is one of the most promising second generation platinum compounds. The low bioavailability (4 to 12%) and the gastrointestinal side effects observed did not warrant further studies with oral administration. The effect of drug sequence on DNA damage and cell death is unknown. Found inside Page 58Carboplatin pharmacokinetics in young children with brain tumors . Cancer Chemother Pharmacol 1996 ; 38 : 395-400 . 106. Jodrell DI , Egorin MJ , Canetta RM For anephric patients where renal function is abolished and GFR as assumed to be zero, dosing of carboplatin can be challenging, as the dosing relies on the nonrenal contribution to . Carboplatin did not bind to plasma protein in vitro but did degrade (t1/2-26 hours) to yield a reactive intermediate that bound rapidly and irreversibly to protein. de Jonge ME(1), Huitema AD, van Dam SM, Rodenhuis S, Beijnen JH. administration were studied in peritoneal fluid, plasma, red blood cells (RBCs), and. 8600 Rockville Pike Unable to load your collection due to an error, Unable to load your delegates due to an error. Drug Saf. The pharmacokinetics of carboplatin were analyzed in 30 patients with advanced lung cancer receiving a total of 48 cycles of carboplatin plus paclitaxel/ docetaxel combination chemotherapy. Bookshelf Commonly, carboplatin is administered intravenously, and its pharmacokinetics are linear up to a dose of 2400 mg/m2. 9 Carboplatin is also indicated for the palliative treatment of ovarian carcinoma, recurrent after prior chemotherapy. Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function CorrespondenceProfessor Alan Boddy, School of Pharmacy and Health Sciences, University of South Australia, Adelaide, SA, Australia. The pharmacokinetics of carboplatin were investigated in cancer patients after single, IV infusion doses of 75, 150, 247.5, 300, 375, and 450 mg/m2. Carboplatin is also used for other types of cancer, including lung, head and neck, endometrial, esophageal, bladder, breast, and cervical; central nervous system or germ cell tumors; osteogenic sarcoma; and as preparation for a stem cell or bone marrow transplant. Carboplatin pharmacokinetics in young children with brain tumors. PURPOSE: Patupilone is a microtubule-targeting chemotherapeutic agent with clinical activity in a broad range of taxane-sensitive/resistant tumor types. Peripheral Nervous System Involvement in Non-Primary Pediatric Cancer: From Neurotoxicity to Possible Etiologies. Prevention and treatment information (HHS). cis-Amminedichloro(2-methylpyridine) platinum(II) (AMD473), a novel sterically hindered platinum complex: in vivo activity, toxicology, and pharmacokinetics in mice. Our in vitro modeling suggests that exposure to O prior to C (O>C) reduced double stranded DNA damage and cell loss. Other. Bookshelf Carboplatin is used to treat ovarian cancer. Platinum (Pt) was determined by atomic absorption spectrometry in plasma ultrafiltrate up to 24 hours and in plasma and urine up to 5 days following infusion. However, carboplatin pre-treatment induced a ~50% faster olaparib clearance. Objective T o determine the pharmacokinetics of carboplatin in sulphurcrested cockatoos, so that its use in clinical studies in birds can be considered.. Design A pharmacokinetic study of carboplatin, following a single intravenous (IV) or intraosseus (IO) infusion over 3 min, was performed in six healthy sulphurcrested cockatoos (Cacatua galerita). Found insideDedrick RL, Myers CE, Bungay PM, DeVita VT, Jr.Pharmacokinetic rationale for Preliminary observations of intra-peritoneal carboplatin pharmacokinetics Carboplatin is a less potent, less emetogenic and much less nephrotoxic analog of cisplatin. We studied the pharmacokinetics of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) and carboplatin administered in combination to 21 patients with advanced non-small cell lung cancer. Pharmacokinetic assessments were performed at 1, 2, 4, and 12 hours after chemotherapy infusion on day 1 of cycle 1. Clinical trials demonstrate that carboplatin's efficacy is close to that of cisplatin for canine osteosarcoma. Carboplatin has a similar spectrum of activity to cisplatin. Its greater chemical stability in comparison with cisplatin accounts for its lower reactivity with nucleophilic sites of DNA, and may therefore be related to the higher dose necessary to obtain an antitumour effect similar to that of cisplatin. Found inside Page 200Plasma free platinum pharmacokinetics in patients treated with high dose carboplatin. Eur J Cancer Clin Oncol 1987;23(9):13991405. Chou TC. Found inside Page 136Calvert , A.H. ( 1987 ) , Plasma free platinum pharmacokinetics in patients treated with high dose carboplatin , Eur.J.Cancer Clin.Oncol . , 23,1399-405 . In comparison with cisplatin, carboplatin has longer half-lives of ultrafilterable platinum (23 and 120 min versus 6 and 36 min for distribution and initial elimination half-lives, respectively) and a higher cumulative urinary platinum excretion (77 versus 28% of the dose in 24 h), both due to the lower protein binding of carboplatin. Carboplatin Dose (mg/m. Careers. Prevention and treatment information (HHS). Consequently, the PK of . Found inside Page 1236In cell suspensions , however , 20-40 - fold more carboplatin than cisplatin It can be concluded that pharmacokinetics of carboplatin reflect its lower The plasma, urinary and biliary clearances of cisplatin and its non-nephrotoxic analogue, Carboplatin (cis-diammine-1,1-cyclobutane dicarboxylate platinum II, CBDCA, JM8) have been determined in mice and rats following intravenous administration of the compounds. This phase I trial was conducted to evaluate drug safety and pharmacokinetics as well as tumor response of sorafenib in combination with paclitaxel and carboplatin in patients with advanced non-small cell . No formal comparison of cisplatin and carboplatin pharmacokinetics was performed. Found insideTable 14.1 Carboplatin Pharmacokinetics Cumulative 24-hr Urinary 65% (if Creatinine Clearance >60 Excretion mL/min) In vitro halflife (H20) 24 hr Plasma PATIENTS AND METHODS Fifty-five chemotherapy-naive patients with NSCLC were entered onto the pharmacokinetic part of a large phase I trial in which P was administered as a 3-hour infusion . Found inside Page 191Pilot pharmacokinetic study of marimastat ( MAR ) in combination with carboplatin ( C ) / paclitaxel ( T ) in patients with metastatic or locally advanced Carboplatin was administered over 30 minutes and paclitaxel over 3 hours every 4 weeks. In the multivariate analysis, factors significantly related to AUC were 1/[Crp] (P < 0.01) and age (P < 0.01). PMC PATIENTS: Plasma carboplatin pharmacokinetics were determined in 57 children (2 months to 18 years old, with serum creatinine levels ranging from 27 to 268 mumol/L . The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non . Our trial tests the hypothesis that C>O causes more cellular injury. Method: Carboplatin pharmacokinetics. MeSH Male SpragueDawley rats were given either cisplatin or carboplatin intravenously at an equitoxic dose (LD 10 or LD . Lung cancer is the leading cause of cancer-related deaths worldwide. The AUC, T1/2 and Cmax of total and free Pt were estimated to be 7.14 and 3.14 mg/ml x min, 35.1 and 18.2 h, and 15.1 and 10.0 micrograms/ml, respectively. Influence of mesna on the pharmacokinetics of cisplatin and carboplatin in pediatric cancer patients. Compared with a control group of patients who received carboplatin alone, the patients receiving the combination Paclitaxel was administered as a 24-hour intravenous infusion at doses of 135 to 200 mg/m 2 Intraperitoneal administration has been used in cases of residual ovarian cancer: as a result of its higher hydrophilicity and higher molecular weight, carboplatin is cleared more slowly from the peritoneal cavity than cisplatin (6 vs 15 ml/min). Would you like email updates of new search results? The purpose of this study was to define the maximal tolerated dose (MTD), extramedullary toxicities, and pharmacokinetics of docetaxel combined with high-dose melphalan and carboplatin with autologous hematopoietic progenitor cell support. Protein binding is limited, while the low uptake in red blood cells appears to be species dependent. Is indicated in combination with cyclophosphamide and its pharmacokinetics and toxicity profile chemotherapeutic agent used to treat cancer interfering! And the gastrointestinal side effects observed did not warrant further studies with oral administration to which compounds. Performed in accordance with institutional guidelines experimental Design: Antitumor activities of cisplatin dose was calculated so as to a. Platinum carboplatin pharmacokinetics plasma ultrafilterable platinum concentrations were determined for carboplatin in a high-dose with! 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